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Effect of Monosaccharides on Intestinal Barrier Function (ENDO-META)

P

Prof. Dr. Ina Bergheim

Status

Completed

Conditions

Dietary Habits
Endotoxemia

Treatments

Other: Dietary Intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT03482284
UVienna18

Details and patient eligibility

About

The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.

Full description

In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.

Enrollment

12 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI <25 kg/m2
  • no kown history of metabolic disorders or fatty liver

Exclusion criteria

  • food allergies or intolerances (esp. fructose intolerance and malabsorption)
  • renal insufficiency
  • chronic disease of the gastrointestinal tract
  • taking drugs affecting lipid or glucose metabolism

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

12 participants in 2 patient groups

Monosaccharide 1
Experimental group
Description:
Participants receive standardized meals with a defined amount of monosaccharide 1.
Treatment:
Other: Dietary Intervention
Monosaccharide 2
Experimental group
Description:
Participants receive standardized meals with a defined amount of monosaccharide 2.
Treatment:
Other: Dietary Intervention

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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