Effect of Monosaccharides on Intestinal Barrier Function (ENDO-META)

Prof. Dr. Ina Bergheim

Status: Completed

Conditions: Dietary Habits; Endotoxemia

Treatments: Other: Dietary Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT03482284

UVienna18

Details and patient eligibility

About

The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.

Full description

In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.

Enrollment: 12 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI <25 kg/m2
• no kown history of metabolic disorders or fatty liver

Exclusion criteria

• food allergies or intolerances (esp. fructose intolerance and malabsorption)
• renal insufficiency
• chronic disease of the gastrointestinal tract
• taking drugs affecting lipid or glucose metabolism

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Monosaccharide 1

Experimental group

Description:

Participants receive standardized meals with a defined amount of monosaccharide 1.

Treatment:

Other: Dietary Intervention

Monosaccharide 2

Experimental group

Description:

Participants receive standardized meals with a defined amount of monosaccharide 2.

Treatment:

Other: Dietary Intervention