Effect of Monosodium Glutamate Supplementation on Gastric Emptying and Postprandial Nitrogen Kinetics

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: NaCl supplementation; Dietary Supplement: MSg supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT00862017

AJI-01

Details and patient eligibility

About

There are receptors to free glutamate in the oral cavity and stomach that may mediate effects of this amino acid on gastrointestinal physiology. The investigators hypothesize that a chronic supplementation of monosodium glutamate (MSG) could modulate gastric emptying and the further metabolism of dietary protein in healthy subjects.

Enrollment: 13 patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 23 to 28

Exclusion criteria

• pregnancy
• allergy to milk protein
• gastrointestinal diseases

Trial design

13 participants in 2 patient groups, including a placebo group

MSG

Experimental group

Description:

Subjects receive a 6-d supplementation of MSG and are studied on the 7th day in the postprandial period following a standard meal ingestion with 2g MSG

Treatment:

Dietary Supplement: MSg supplementation

Control

Placebo Comparator group

Treatment:

Dietary Supplement: NaCl supplementation