Effect Of Moringa Leaf Extract On Disease Activity In Rheumatoid Arthritis Patients

Universitas Sebelas Maret

Status and phase: Completed; Phase 2; Phase 1

Conditions: Rheumatoid Arthritis

Treatments: Drug: Moringa Oleifera

Study type: Interventional

Funder types: Other

Identifiers

NCT05665985

NAP01

Details and patient eligibility

About

Intervention therapy study of moringa oliefera extract on the degree of activity of rheumatoid arthritis patients. The research subjects were patients with rheumatoid arthritis-intervention with moringa oliefera for 30 days.

Full description

Rheumatoid arthritis is a progressive autoimmune disease. Delay in therapy and delay in remission will result in disability. This study is a randomized clinical trial using a new drug for rheumatoid arthritis, moringa oliefera. The choice of moringa oliefera was due to the ability of moringa oliefera in anti-inflammatory and immunosuppressant terms. This drug has also been proven in experimental studies on rheumatoid arthritis animals. This study with 30 research samples divided into two groups, containing 15 samples each for the treatment group and 15 for the control group. The treatment group was given Moringa oleifera extract of 40.50 mg/KGBW/day, while the control group was given a placebo for 30 days.

Enrollment: 30 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of RA criteria according to the ACR / EULAR 2010
• Visual analog score of more than three.

Exclusion criteria

• Pregnancy
• Using Methylprednisolone> 8 mg per day
• Using NSAIDs
• Chronic Kidney Disease
• Diabetes Mellitus
• Heart Failure
• Lever disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

Moringa Oliefera

Experimental group

Description:

Intervention with Dry Extract of Moringa Oleifera (trade name is Keloreena Ⓡ , registered number in National Food and Drug Registry: 193332021) The dose given is 1000 mg bi in day for 30 days.

Treatment:

Drug: Moringa Oleifera

Placebo

Placebo Comparator group

Description:

Capsules similar to moringa oliefera, which contain powder, have no pharmacological effect.

Treatment:

Drug: Moringa Oleifera