Effect of Moringa Oleifera Leaf Extract on Postoperative Pain and Bacterial Reduction in Mandibular Premolars

Cairo University (CU)

Status and phase

Not yet enrolling

Phase 3

Phase 2

Conditions

Necrotic Pulp

Treatments

Drug: Sodium hypochlorite

Dietary Supplement: Moringa oleifera leaf

Study type

Interventional

Funder types

Other

Identifiers

NCT05348824

ENDO 3 -7 -1

Details and patient eligibility

About

The aim of this study is to clinically compare the intensity of post-operative pain and the amount of bacterial reduction after using Moringa oleifera leaf extract solution during chemo-mechanical preparation, versus 2.5% NaOCl, in asymptomatic necrotic mandibular premolars treated in a single visit

Enrollment

30 estimated patients

Sex

All

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Systematically healthy patient (ASA I,II).
Age between 20 and 55 years
Male or female.
Asymptomatic mandibular premolar teeth diagnosed with pulp necrosis with apical periodontitis.
Radiographic examination using Digora intraoral periapical sensor plate and software (Digora; Soredex, Helsinki, Finland) showing mandibular premolars with (smaller than 3 mm (0-2 mm)) periapical radiolucency.

Exclusion criteria

Medically compromised patients having significant systemic disorders. (ASA III or IV).
History of intolerance to NSAIDS.
Teeth with:
- Immature roots
- Vital pulp tissues.
- Association with swelling.
- Acute peri-apical abscess or acute exacerbation of a chronic abscess.
- Mobility Grade II or III.
- Previously accessed or endodontically treated
- Deep periodontal pockets more than 4 mm
- Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions.
Patients who could not interpret the NRS.
Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.