Effect of Moringa Oleifera Mouthwash

Riphah International University

Status: Unknown

Conditions: Orthodontic Appliance Complication

Treatments: Other: Moringa Oleifera Mouthwash; Other: Placebo Mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT05191069

MINS/69/2020 Rabia Afreen

Details and patient eligibility

About

Improvement of oral hygiene maintenance is very important during fixed orthodontic appliance treatment to prevent the degenerative effects. Different mouthwashes are available in market but this study is being conducted to check the effects of Moring Oleifera mouth wash against the development of Gingivitis, Periodontitis, Plaque formation, Enamel Demineralization /white spot lesion, discoloration and bacterial load in dental plaque during the fixed orthodontic treatment.

Full description

With the increase in desire of improved facial and dental aesthetics among all social classes, the numbers of cases being treated with fixed orthodontic appliances are increasing. It is difficult to maintain certain standard of oral hygiene with the braces on, so the iatrogenic degenerative effects of fixed orthodontic appliances are somewhat inevitable. Along with proper brushing and flossing orthodontists advise the use of mouthwash as well in order to prevent or lessen the severity of gingivitis, periodontitis, gingival hyperplasia, demineralization, white spot lesions, discoloration of teeth etc.

Plenty of mouth washes are available in market containing varying concentration of different chemicals promising to improve the oral health and reduce inflammation. But all of them having certain side effects most common being the discoloration. The focus is being shifted to natural ingredients to gain the same or even better results with minimum to zero side effects. In quest of getting closer to Mother Nature Moringa Oleifera leaf was discovered in 1785 in Indian Subcontinent.

Moringa Oleifera is a nutraceutical and well known for its anti-inflammatory, anti-microbial, anti-cancer, anti-diabetes, anti-rheumatoid arthritis, hepatoprotective, Steroid-genesis modulators and neuroprotective functions and many other properties. Its leaves evidently contain various natural anti-inflammatory and anti-oxidant substances namely flavonoid, phenolic and carotenoid. Besides, MO leaves also rich in protein, vitamin C, vitamin A, calcium and potassium. Flavonoids may act as antioxidant by scavenging free radical and protecting the cell from oxidative stress. Recently quite a lot work has been done on flavonoids in dentistry which includes anti-bacterial/anti-cariogenic effects, reduction in plague formation, Treatment in surgical wounds, reduction in dentinal hypersensitivity, treatment of periodontitis and gingivitis because of its anti-inflammatory and anti-oxidative effects.

Previously studies have been done to check the efficacy of different herbal mouthwashes but no study has been done to check the efficacy of MO leaf extract mouth wash on the oral health of the patients having fixed orthodontic treatment

Enrollment: 50 estimated patients

Sex: All

Ages: 13 to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Young healthy subjects undergoing orthodontic treatment.
• Patients with all permanent teeth present without any oral pathology.
• Healthy gingiva with no bleeding on probing before start of orthodontic treatment and a normal pocket depth (1-3mm) on all teeth.
• No WSLs (score = 1

Exclusion criteria

• History of smoking, patients suffering from any systemic illness like diabetes.
• Gingivitis or an active periodontal disease.
• Carious lesions on labial/buccal surface of teeth.
• Mentally handicapped individuals

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

Moringa Oleifera Mouthwash

Experimental group

Description:

15ml of Moringa Oleifera mouthwash will be given to be used twice daily for 6 months.

Treatment:

Other: Moringa Oleifera Mouthwash

Placebo Mouthwash

Placebo Comparator group

Description:

The mouthwash will have all other ingredients other than Moringa Oleifera extract. Participants will be advised to use 15ml of Placebo mouthwash twice daily for 6 months.

Treatment:

Other: Placebo Mouthwash