Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

Cairo University (CU)

Status and phase: Not yet enrolling; Early Phase 1

Conditions: Intracanal Medication; N-acetylcystine; Mediators; Calcium Hydroxide

Treatments: Drug: Calcium hydroxide; Drug: N-acetyl cysteine

Study type: Interventional

Funder types: Other

Identifiers

NCT05666089

safwaendo91

Details and patient eligibility

About

To compare the effect of N-acetylcysteine versus calcium hydroxide as intra canal medication on:

• Intensity of postoperative pain.
• Bacterial load reduction.
• levels of MMP -9 in Periapical Fluids.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who are free from any physical or mental handicapping condition.

• Males & Females with

  • Mandibular single rooted permanent premolar teeth.
  • Absence of spontaneous pain.
  • Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2*2 mm radiographically.

• Patients' acceptance to participate in the trial.

• Patients who can understand pain scale and can sign the informed consent (Appendix I)

Exclusion criteria

1. Medically compromised patients.
2. Pregnant women
3. Patients undergoing previous endodontic treatment or analgesics and/or antibiotics have been administrated by the patient during the past 24 hours preoperatively.
4. Patients reporting bruxism or clenching.
5. Teeth that show association with acute periapical abscess and swelling.
6. Greater than grade I mobility or pocket depth greater than 5mm.
7. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam
8. Teeth with vital pulp.
9. Immature teeth.
10. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

N-acetylcysteine

Experimental group

Description:

intracanal medication of NAC paste

Treatment:

Drug: N-acetyl cysteine

Calcium hydroxide

Active Comparator group

Description:

intracanal medication of Ca(OH)2 paste

Treatment:

Drug: Calcium hydroxide