Effect of Nasal CPAP on Cardiopulmonary Exercise Testing in Patients With Overlap Syndrome

University of Oklahoma (OU)

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease; Obstructive Sleep Apnea

Treatments: Diagnostic Test: CPET

Study type: Observational

Funder types: Other

Identifiers

NCT01033266

14587/2895

Details and patient eligibility

About

Nasal CPAP will improve cardiopulmonary exercise test (CPET) performance in patients with overlap syndrome(COPD and OSA). Nasal CPAP is proven to improve cardiopulmonary exercise testing in patients with OSA. The investigators hypothesis is that patients with overlap syndrome will have a greater improvement in their cardiopulmonary exercise testing besides a possible improvement in their lung function test and airway resistance.

Full description

Patients presenting to the Oklahoma City VA sleep clinic with obstructive sleep apnea syndrome and a desire to initiate CPAP treatment will be included if they have overlap syndrome. Patients will undergo a spirometry and CPET before being started on CPAP as part of standard clinical care. The CPET will be repeated after 8-12 weeks of CPAP use. Patients will be excluded if they have any contraindication to mild exercise or they cannot perform an exercise test due to limited mobility.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obstructive sleep apnea (OSA)
• COPD

Exclusion criteria

• Inability to perform exercise test due to musculoskeletal limitation
• Cardiac condition preventing patient from mild exercise
• Continuous oxygen supplement

Trial design

12 participants in 1 patient group

CPET CPAP

Treatment:

Diagnostic Test: CPET