Effect of Natural Compounds on the Severity of HPV-induced Cervical Lesions

Lo.Li.Pharma

Status: Completed

Conditions: Papilloma; Cervix Lesion

Treatments: Dietary Supplement: Epigallocatechin gallate, Folic acid, Vitamin B12, and Hyaluronic Acid

Study type: Interventional

Funder types: Industry

Identifiers

NCT05625308

HPV-NAT-COM

Details and patient eligibility

About

To test the efficacy of a newly-commercialized formula, 40 HPV-positive women displaying chronic cervicitis, mild dysplasia or moderate dysplasia. Women in the study group took one tablet per day containing 200 mg of EGCG, 400 mcg of Folic Acid, 1 mg of Vitamin B12 and 50 mg of Hyaluronic Acid for twelve weeks. Women in the control group received no treatment.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HPV infections
• Occurrence of low-grade cervical lesions

Exclusion criteria

• Diagnosis of malignancy or severe cervical lesions
• Concurrent uterine pathologies
• Pregnancy or intended to seek pregnancy in the next three months
• Cancer

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Co-treatment with EGCG, FA, B12, and HA

Experimental group

Description:

One tablet per day containing 200 mg of EGCG, 400 mcg of Folic Acid, 1 mg of Vitamin B12 and 50 mg of Hyaluronic Acid for twelve weeks.

Treatment:

Dietary Supplement: Epigallocatechin gallate, Folic acid, Vitamin B12, and Hyaluronic Acid

Control

No Intervention group

Description:

Untreated women.