Effect of Nebulized Lidocaine on Postoperative Sore Throat

Antalya Training and Research Hospital

Status: Terminated

Conditions: Sore Throat

Treatments: Other: Lidocaine; Other: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03779516

AntalyaTRH 28

Details and patient eligibility

About

The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.

Full description

Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization).

At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.

Enrollment: 110 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing video-assisted thoracic surgery requiring double lumen tube endotracheal intubation for one-lung ventilation
• American Society of Anesthesiologists class 1,2 and 3
• Ability to consent

Exclusion criteria

• patients <18 years old
• body mass index (BMI) <20 or >35 kg/m2
• Mallampati grade 3 or 4
• mouth opening < 3 cm
• preexisting hoarseness or sore throat
• coagulopathy
• patient with upper respiratory tract infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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110 participants in 2 patient groups

Group C

Active Comparator group

Description:

In Control Group, 4 mL of saline solution was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min

Treatment:

Other: Saline

Group L

Active Comparator group

Description:

In Lidocaine Group 4 mL of 4% lidocaine was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min

Treatment:

Other: Lidocaine