Effect of Need to Void on Parkinsonian Gait

Pierre and Marie Curie University

Status: Completed

Conditions: Lower Urinary Tract Symptoms; Gait Disorders, Neurologic; Parkinsonism

Treatments: Other: Gait speed

Study type: Observational

Funder types: Other

Identifiers

NCT03314610

P. GREEN 001

Details and patient eligibility

About

This study evaluates the effect of the need to void on parkinsonian gait

Full description

Parkinsonian syndromes are common causes of gait disorders, associated with hypometria, bradykinesia or rigidity. If motor disorders are the most visible part, lower urinary tract dysfunction is one of the most prevalent dysautonomic disorder (27-80%), especially over active bladder syndrome (OAB). If it seems evident that gait and urinary disorders are linked, because of similar anatomic pathways and control processes, no studies have investigated their association in extrapyramidal patients.

The aim of this study is to assess the effect of the need to void on the walking speed in this particular population.

This prospective study inclues all parkinsonian syndromes who had a follow-up for OAB. They must have a security delay over five minutes, no severe cognitive, motor or psychiatric disorders. We invite them to drink until a need to void (or equivalent). Bladder filling is measured by bladder scan, then they performe gait tests in a specific place, with calm and no passage : Patient can use their habitual walking device. Speed walk asking is comfortable for the two test. Three ten-meter tests, one double-task ten-meter test, one timed-up-and-go test, one timed raise of the floor (GMT). We repeat the same tests after voiding or self-catheterization. Toilets are just next to the hall where they realize the tests. A clinical examination assesses urinary dysfunction (USP, IPSS), motor score (UPDRS-III, Hoehn and Yahr scale, daily equivalent of levodopa), history of falls and comorbidities.

Enrollment: 11 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinsonian syndromes
• Follow in neurourology for Lower urinary tract symptoms
• Able to walk 50 meters without human assistance
• able to hold voiding for more than 3 minutes

Exclusion criteria

• Actual urinary tract infection
• Montreal cognitive assessment < 20/30
• Acute psychiatric or neurologic disorders who can interfer with walking tests

Trial design

11 participants in 1 patient group

Patients enrolled

Description:

Patient with parkinsonian syndromes and lower urinary tract symptoms, age \> 18, able to walk without human help on 50 meters, able to hold urine at least 3 minutes. A first record of gait speed will be at strong desire to void. A second record will be after voiding or catheterization Gait records consist on : 3x 10 meter walk test, 1x double task 10 meter walk test, 1x Timed up and Go test and 1x GMT

Treatment:

Other: Gait speed