Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers

Hadassah Medical Center

Status

Unknown

Conditions

Tobacco Use Disorder

Nicotine Dependence

Nicotine Use Disorder

Smoking

Treatments

Drug: Nicotine

Study type

Interventional

Funder types

Other

Identifiers

NCT00429208

yakir@hmo

Details and patient eligibility

About

This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among young women. Nicotine has short- term, facilitating effects on attention and response inhibition. Therefore, individuals who are impaired on cognitive functions such as these and initiate cigarette smoking may be more likely to maintain the habit and develop nicotine dependence. The research protocol specifically tests whether administration of nicotine to non-abstinent, regular cigarette smokers improves cognitive function in those domains where the participants had previously been shown to manifest performance deficits

Enrollment

40 estimated patients

Sex

Female

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Reported smoking cigarettes on a daily basis at the time of the original study and continue to smoke currently
Manifested poor performance on the MFFT (The neurocognitive test that yielded differences between smokers and non-smokers)
Competent and willing to give written informed consent

Exclusion criteria

Pregnancy, breast-feeding, non-use of contraception such that the possibility of pregnancy cannot be excluded
Intake of any medication that may potentially interact with nicotine.
Any current or past medical condition that represents a contra-indication to nicotine administration.