Effect of Nigella Sativa on Nonalcoholic Steatohepatitis and Steatosis (NASH NAFLD)

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Liver Steatosis; Nonalcoholic Steatohepatitis

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Nigella Sativa

Study type: Interventional

Funder types: Other

Identifiers

NCT02307344

0002-14-HYMC

Details and patient eligibility

About

The investigators hypothesize that Nigella Sativa will have an effect on Nonalcoholic Steatohepatitis and Liver Steatosis by enhancing lipophagy in the liver tissue.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients suffering from Steatohepatitis
• Patients suffering from Liver Steatosis

Exclusion criteria

• Patients suffering from viral hepatitis
• Patients with HIV infection
• Patients suffering from Wilsons Disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Nigella Sativa Supplement

Active Comparator group

Description:

Fifty patients suffering from Nonalcoholic Steatohepatitis or Liver Steatosis will ingest capsules containing 2 grams of Nigella Sativa divided into 1 grams twice a day.

Treatment:

Dietary Supplement: Nigella Sativa

Patients receiving a placebo tablet

Active Comparator group

Description:

Twenty patients suffering from Nonalcoholic Steatohepatitis or Liver Steatosis will ingest placebo capsules twice a day, that look like the capsules of those receiving the Nigella Sativa.

Treatment:

Dietary Supplement: Placebo