Effect of Nitrate on Red Blood Cell Function in Type 2 Diabetes

Karolinska Institute

Status: Enrolling

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: Beet root juice; Dietary Supplement: Placebo juice

Study type: Interventional

Funder types: Other

Identifiers

NCT04917471

NOBLE-DM

Details and patient eligibility

About

To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Type 2 diabetes

Exclusion criteria

Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction <35%) Any condition that interferes with the possibility to fulfill the study protocol

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups, including a placebo group

Nitrate-rich beet root juice

Active Comparator group

Description:

Nitrate-rich Beet root juice 70 ml bid

Treatment:

Dietary Supplement: Beet root juice

Placebo

Placebo Comparator group

Description:

Nitrate-depleted beet root juice 70 ml bid

Treatment:

Dietary Supplement: Placebo juice