Effect of Nitrate-rich Beetroot Juice on Exercise Performance in Heart Failure Patients

Brooke Army Medical Center

Status: Completed

Conditions: Systolic Heart Failure

Treatments: Dietary Supplement: nitrate-rich beetroot juice; Dietary Supplement: nitrate-deplete beetroot juice

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT02223403

383967-4

Details and patient eligibility

About

Nitrate-rich beetroot juice supplementation has demonstrated reduced oxygen consumption and submaximal exercise performance in healthy adults. Investigation for similar effects in patients with heart failure has not previously been conducted.

This was a randomized, double-blind, placebo controlled trial. Following ingestion of the active agent or placebo, subjects with systolic heart failure underwent submaximal steady state exercise with gas exchange analysis followed thirty minutes later by a six minute walk test. Second testing sessions were performed ten days.

There were no significant differences in the treatment and placebo arms in average oxygen consumption or six minute walk distance.

In conclusion, in patients with heart failure who have ingested a single dose of nitrate-rich beetroot juice concentrate, there is no significant difference with regard to oxygen consumption during submaximal steady state exercise or six minute walk testing distance.

Further study is warranted to determine the true efficacy of nitrate consumption in this population with adjustments in acute or chronic dosing, exercise duration, or intensity.

Enrollment: 12 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Local institutional beneficiaries between the ages of 18 and 80
• Documentation of left ventricular systolic dysfunction with ejection fraction < 40% by any modality within the past six months
• Documentation of New York Heart Association class II or III status.

Exclusion criteria

• > 80 years of age
• Unable to adequately or safely perform treadmill exercise
• Pulmonary disease deemed significant enough to be a limitation to exercise
• Greater than moderate stenotic or regurgitant valvular heart disease
• Presence of atrial fibrillation or other uncontrolled arrhythmias
• Uncompensated heart failure
• Continuously paced rhythms
• Pregnant females
• Chronic nitroglycerine use (oral isosorbide di or mono-nitrate, or topical nitroglycerine)
• Phosphodiesterase inhibitor (sildenafil or tadalafil) use within a week

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 2 patient groups

submaximal steady state exercise

Experimental group

Description:

90 minutes after respective beetroot juice ingestion, subjects walked on treadmill at a pre-determined steady state workload for a total of 15 minutes with oxygen consumption recorded for the last 10 minutes

Treatment:

Dietary Supplement: nitrate-deplete beetroot juice

Dietary Supplement: nitrate-rich beetroot juice

six minute walk test

Experimental group

Description:

subjects performed six-minute walk at self-determined pace 30 minutes after treadmill exercise was performed

Treatment:

Dietary Supplement: nitrate-deplete beetroot juice

Dietary Supplement: nitrate-rich beetroot juice