Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic Pain After Hysterectomy

NeuroTherapia, Inc.

Status: Withdrawn

Conditions: General Anesthesia; Nitrous Oxide; Abdominal Hysterectomy (& Wertheim)

Treatments: Drug: Nitrous oxide; Other: General anesthesia with oxygen

Study type: Interventional

Funder types: Other

Identifiers

NCT01622335

1491-952

Details and patient eligibility

About

The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups.

Full description

The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 65 years old at time of the first procedure
• Female
• American Society of Anesthesiologists physical status I or II
• Hysterectomy undergoing the general anesthesia

Exclusion criteria

• Neuropathic disease
• Chronic opioid users
• Contraindication for Nitrous Oxide receive
• Consent will not be obtained patient
• Psychiatric disorders
• Current or recent drug abuse (within past 6 months).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups, including a placebo group

General anesthesia with oxygen

Placebo Comparator group

Description:

General anesthesia and Air

Treatment:

Other: General anesthesia with oxygen

nitrous oxide and general anesthesia

Experimental group

Description:

General anesthesia with Nitrous Oxide

Treatment:

Drug: Nitrous oxide