Effect of NLR and MPV on Early Postoperative Outcome in Lower Extremity Arthroplasty Operations

Akdeniz University

Status: Completed

Conditions: Knee Arthropathy

Study type: Observational

Funder types: Other

Identifiers

NCT03148951

MANLOP

Details and patient eligibility

About

In the planned study the investigators want to evaluate the relation between postoperative complications and minor/ major morbidities, mortality and Mean Platelet Volume (MPV) and Neutrophil/ lymphocyte (N/L) ratio.

Full description

• In this study the investigators aim to determine the relation between the MPV and N/L ratio and the incidence of postoperative adverse events and complications in patients undergoing knee arthroplasty.
• In this study only the laboratory tests that are routinely used for the operative patients are going to be used and no extra tests will be performed. The study will begin after the postoperative blood samples are collected for routine laboratory measurements. The patients will be allocated to 4 groups according to the type of anesthesia and VAS scores. Preoperative and postoperative peripheral blood total whole blood MPV and N/L ratio and 1st 6th 12th ve 24th hours VAS scores and complications, morbidities and mortality will be recorded. The patients will receive analgesics according to the routine practice in the ward and the doses of analgesics given will be recorded at 1st 6th 12th ve 24the hours wil be recorded.
• Statistical analysis: the numerical variables will be analyzed tested with Kolmogorov-Smirnov test for normality. For the parametric variables that are normally distributed t-test will be used for the comparison between groups. For the parametric variables that are not normally distributed Mann Whitney-U test will be used. All the categorical variables will be evaluated with q- square tests. A p value < 0.05 will be determined as statistically significant.

Enrollment: 754 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• knee arthroplasty patients with general or spinal anesthesia.

Exclusion criteria

• patients not giving consent
• reoperations
• patients having inflammatory disease
• infection in the knee
• sepsis
• bleeding disorders
• hematologic diseases,
• using steroids.
• trauma
• fracture patients,
• bilateral knee prothesis
• combined surgery procedures
• patients needing perioperative transfusions
• uncooperative patients.

Trial design

754 participants in 4 patient groups

Group 1

Description:

Group 1: patients receiving general anesthesia and having a postoperative pain VAS score equal to or below 50 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 2

Description:

Group 2: patients receiving general anesthesia and having a postoperative pain VAS score equal to or above 60 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 3

Description:

Group 3: patients receiving regional (spinal) anesthesia and having a postoperative pain VAS score equal to or below 50 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 4

Description:

Group 4: patients receiving spinal anesthesia and having a postoperative pain VAS score equal to or above 60 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.