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Effect of NO Precursors on Physiological Responses to Exercise (NO-SUP)

Grenoble Alpes University Hospital Center (CHU) logo

Grenoble Alpes University Hospital Center (CHU)

Status

Completed

Conditions

Physiology

Treatments

Biological: Evaluation of post-ischemic vascular reactivity
Dietary Supplement: Placebo
Biological: Neuromuscular evaluations
Dietary Supplement: Nitrate and L-Citrulline
Dietary Supplement: Nitrate and L-Arginine
Dietary Supplement: Nitrate

Study type

Interventional

Funder types

Other

Identifiers

NCT02850367
38RC14.430

Details and patient eligibility

About

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Enrollment

63 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Sedentary subjects
  • No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion criteria

  • Body mass index > 28 kg.m-2
  • Smoker
  • Alcool intake > 10g/day
  • Psychiatric diseases
  • Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

63 participants in 2 patient groups

Acute intake
Active Comparator group
Description:
Evaluation after acute intake of the food supplement.
Treatment:
Biological: Neuromuscular evaluations
Dietary Supplement: Nitrate and L-Citrulline
Dietary Supplement: Nitrate and L-Arginine
Dietary Supplement: Nitrate
Biological: Evaluation of post-ischemic vascular reactivity
Dietary Supplement: Placebo
Chronic intake
Active Comparator group
Description:
Evaluation before and after chronic intake of the food supplement.
Treatment:
Biological: Neuromuscular evaluations
Dietary Supplement: Nitrate and L-Citrulline
Biological: Evaluation of post-ischemic vascular reactivity
Dietary Supplement: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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