Effect of NO Precursors on Physiological Responses to Exercise (NO-SUP)

Grenoble Alpes University Hospital Center (CHU)

Status: Completed

Conditions: Physiology

Treatments: Biological: Evaluation of post-ischemic vascular reactivity; Dietary Supplement: Placebo; Biological: Neuromuscular evaluations; Dietary Supplement: Nitrate and L-Citrulline; Dietary Supplement: Nitrate and L-Arginine; Dietary Supplement: Nitrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02850367

38RC14.430

Details and patient eligibility

About

NO is an ubiquitous molecule contributing to many physiological functions such as vasodilation, immune and oxidative stress responses. NO production can be supplemented either by providing substrate to the NO-synthase (L-Arginine and L-Citruline) or by providing nitrate which can lead to NO. In the present project the investigators evaluate the effect of various acute and chronic oral NO precursors supplementation on exercise performance and responses in healthy young and older subjects.

Enrollment: 63 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Sedentary subjects
• No cardiovascular, respiratory, metabolic and neurological disorders

Exclusion criteria

• Body mass index > 28 kg.m-2
• Smoker
• Alcool intake > 10g/day
• Psychiatric diseases
• Subjects under treatment able to interfere with their cardiovascular, metabolic and neurological status

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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63 participants in 2 patient groups

Acute intake

Active Comparator group

Description:

Evaluation after acute intake of the food supplement.

Treatment:

Biological: Neuromuscular evaluations

Dietary Supplement: Nitrate and L-Citrulline

Dietary Supplement: Nitrate and L-Arginine

Dietary Supplement: Nitrate

Biological: Evaluation of post-ischemic vascular reactivity

Dietary Supplement: Placebo

Chronic intake

Active Comparator group

Description:

Evaluation before and after chronic intake of the food supplement.

Treatment:

Biological: Neuromuscular evaluations

Dietary Supplement: Nitrate and L-Citrulline

Biological: Evaluation of post-ischemic vascular reactivity

Dietary Supplement: Placebo