Effect of Nocturnal Administration of Anti-hypertensive Medications in NoN-dippers

Yonsei University

Status and phase: Completed; Phase 4

Conditions: Hypertension

Treatments: Drug: Valsaltan, amlodipine

Study type: Interventional

Funder types: Other

Identifiers

NCT01091753

4-2007-0440

Details and patient eligibility

About

The purpose of this study is to determine the effect of nocturnal administration of Anti-hypertensive medications in Non-dippers.

Efficacy variables.

1. ECHO
2. 24hr. horter
3. IMT
4. BUN/crea, urine analysis (microalbulinuria
5. Cardio vascular event. "

Enrollment: 28 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Essential hypertension (stage 1-2)
2. 24hr. holer : non-dipper
3. Age 18 ~70.

Exclusion criteria

1. Any known malignant disease
2. Renal failure , creatinine >2.0mg/dl
3. Liver disease

Trial design

28 participants in 2 patient groups, including a placebo group

morning administration group

Placebo Comparator group

Treatment:

Drug: Valsaltan, amlodipine

nocturnal administration group

Experimental group

Treatment:

Drug: Valsaltan, amlodipine