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Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes (EA3)

U

University of Toronto

Status

Completed

Conditions

Healthy
Increased Metabolic Requirement

Treatments

Dietary Supplement: large amount of essential amino acids
Dietary Supplement: BCAA-enriched egg protein
Dietary Supplement: small amount of essential amino acids
Dietary Supplement: BASE egg protein

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02874638
IAAO-EA3

Details and patient eligibility

About

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

The biological value of protein depends on its amino acid composition. Essential amino acids are believed to have main role on whole body protein metabolism. However, it remains to be determined what role non-essential amino acids (NEAA) may have in regulating protein metabolism and contributing to the increased protein requirements after endurance exercise.

The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. However, the IAAO method has never been utilized for assessing the effect of NEAA on protein requirements after endurance exercise.

The objective of the current study is to investigate the importance of NEAA for endurance-trained male subjects.

Enrollment

7 patients

Sex

Male

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • endurance-trained participants who regularly run more than 40 km/week
  • Participants who are categorized at least "very good" based on a study by Shvartz & Reibold, in which VO2peak is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y)
  • Ability to complete the 16-km familiarization run in session 2

Exclusion criteria

  • Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
  • Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
  • Regular tobacco use
  • Illicit drug use

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

7 participants in 4 patient groups

BASE egg protein
Experimental group
Description:
0.8 g/kg/d of BASE protein provided as crystalline amino acid made after egg protein.
Treatment:
Dietary Supplement: BASE egg protein
BCAA-enriched egg protein
Experimental group
Description:
branched-chain amino acid-enriched egg protein
Treatment:
Dietary Supplement: BCAA-enriched egg protein
small amount of essential amino acids
Experimental group
Description:
small amount of essential amino acids made after egg protein, which is equivalent to the amount of essential amino acids in BASE
Treatment:
Dietary Supplement: small amount of essential amino acids
large amount of essential amino acids
Experimental group
Description:
large amount of essential amino acids made after egg protein, which is equivalent to the amount of amino acids in BCAA
Treatment:
Dietary Supplement: large amount of essential amino acids

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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