ClinicalTrials.Veeva

Menu

Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers

M

Mahidol University

Status

Completed

Conditions

Periodontitis
Coronary Heart Disease

Treatments

Procedure: non-surgical periodontal treatment

Study type

Observational

Funder types

Other

Identifiers

NCT04305171
MU-DT/PY-IRB 2018/022.0504

Details and patient eligibility

About

The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.

Full description

CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.

Enrollment

28 patients

Sex

All

Ages

35 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months)
  • had at least 14 natural teeth excluding third molars

Exclusion criteria

  • received anticoagulant drugs
  • had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
  • pregnancy or lactation
  • presence or history of other infections
  • periodontal treatment within 6 months
  • tooth extractions within 2 months prior to the study.

Trial design

28 participants in 4 patient groups

coronary heart disease patients with periodontitis
Description:
Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.
Treatment:
Procedure: non-surgical periodontal treatment
coronary heart disease patients without periodontitisHD
Description:
Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Non-periodontitis classified as having PD ≤ 3 mm.
Treatment:
Procedure: non-surgical periodontal treatment
non-coronary heart disease patients with periodontitis
Description:
Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.
Treatment:
Procedure: non-surgical periodontal treatment
non-coronary heart disease patients without periodontitis
Description:
Non-periodontitis classified as having PD ≤ 3 mm.
Treatment:
Procedure: non-surgical periodontal treatment

Trial contacts and locations

3

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems