Effect of Non-surgical Periodontal Treatment on Cardiovascular Risk Markers

Mahidol University

Status: Completed

Conditions: Periodontitis; Coronary Heart Disease

Treatments: Procedure: non-surgical periodontal treatment

Study type: Observational

Funder types: Other

Identifiers

NCT04305171

MU-DT/PY-IRB 2018/022.0504

Details and patient eligibility

About

The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.

Full description

CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.

Enrollment: 28 patients

Sex: All

Ages: 35 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months)
• had at least 14 natural teeth excluding third molars

Exclusion criteria

• received anticoagulant drugs
• had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months
• pregnancy or lactation
• presence or history of other infections
• periodontal treatment within 6 months
• tooth extractions within 2 months prior to the study.

Trial design

28 participants in 4 patient groups

coronary heart disease patients with periodontitis

Description:

Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.

Treatment:

Procedure: non-surgical periodontal treatment

coronary heart disease patients without periodontitisHD

Description:

Coronary heart disease patients confirmed through coronary angiography as having at least 50% diameter stenosis in at least one coronary artery and clinically stable with the absence of any potentially confounding inflammatory conditions for at least 6 months. Non-periodontitis classified as having PD ≤ 3 mm.

Treatment:

Procedure: non-surgical periodontal treatment

non-coronary heart disease patients with periodontitis

Description:

Periodontitis classified as havingbleeding on probing (BOP), pocket depth (PD) \> 4 mm, clinical attachment level (CAL) ≥ 5 mm and radiographic evidence of bone loss were presented at the same site of at least 4 teeth.

Treatment:

Procedure: non-surgical periodontal treatment

non-coronary heart disease patients without periodontitis

Description:

Non-periodontitis classified as having PD ≤ 3 mm.

Treatment:

Procedure: non-surgical periodontal treatment