Effect of Non-surgical Periodontal Treatment on Oxidative Stress and Antioxidant Status in OSAS

Bezmialem Vakif University

Status: Completed

Conditions: Periodontitis; OSAS; Obstructive Sleep Apnea

Treatments: Other: Control; Other: Experimental

Study type: Interventional

Funder types: Other

Identifiers

NCT03268473

boz001

Details and patient eligibility

About

The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.

Full description

There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased oxidative stress markers.

The investigators aimed to investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged ≥18 years old
• having more than 16 teeth
• BMI>25 kg/m2

Exclusion criteria

• patients with a history of diabetes mellitus or respiratory diseases
• patients who were under any medication that was known to influence periodontal tissues
• patients with a history of any periodontal treatment in the past 6 months
• patients with hormonal changes such as pregnancy or lactation; and 5) patients having fixed dentures or removable prothesis
• OSAS treatment started (using OSAS therapy device or undergoing surgical operation)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Experimental: Non-surgical periodontal therapy in patient with OSAS and Periodontitis

Experimental group

Description:

Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: with both OSAS and periodontitis Intervention: Procedure: Non-surgical periodontal therapy

Treatment:

Other: Experimental

Control: non-surgical periodontal therapy in Periodontitis

Active Comparator group

Description:

Non-surgical periodontal therapy consisted of scaling and root planing and supportive periodontal therapy during 3 months Individuals: only periodontitis Intervention: Procedure: Non-surgical periodontal therapy

Treatment:

Other: Control