Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension

University of Zurich (UZH)

Status: Completed

Conditions: Pulmonary Hypertension

Treatments: Other: Hypoxia and Hyperoxia

Study type: Observational

Funder types: Other

Identifiers

NCT03195959

KEK-ZH-Nr. 2016-02136

Details and patient eligibility

About

Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities at moderate altitude or bring up the question of air-travel.

Still very few is known about the effects hypoxic conditions have on PH patients. The aim of this study is to investigate the effects of hypoxia in comparison to normoxia and hyperoxia on pulmonary hemodynamics in patients with pulmonary hypertension during routine right heart catheterisation. We aim to get insight into the pathophysiology of pulmonary hemodynamics under hypoxic conditions in comparison to normoxia and hyperoxia in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension compared with control patients, that are scheduled for right heart catheterisation due to dyspnea but have no PH.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinically indicated right heart catheterisation
• diagnosis of pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension or control without pulmonary hypertension

Exclusion criteria

• hemodynamically unstable
• partial pressure of Oxygen < 7.3kPa
• no informed consent
• pulmonary hypertension due to left heart disease, chronic lung disease or miscellaneous (Groups II, III and V) according to Galié ERJ 2015

Trial design

44 participants in 2 patient groups

PH-Patients

Description:

Patients with mean pulmonary artery pressure \>25mmHg and a pulmonary arterial wedge pressure \<15mmHg during right heart catheterisation, which are diagnosed as having pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension.

Treatment:

Other: Hypoxia and Hyperoxia

Control group

Description:

Patients with clinically indicated right heart catheterisation (because of dyspnea or other signs of PH), but had no PH (no elevated mean pulmonary artery pressure (mPAP \<20mmHg)).

Treatment:

Other: Hypoxia and Hyperoxia