Effect of Nutrition Supplementation Combined With Resistance Exercise in Elderly With Sarcopenia.

Taipei Medical University

Status: Completed

Conditions: Sarcopenia

Treatments: Dietary Supplement: soy milk supplement; Dietary Supplement: milk supplement; Behavioral: resistance exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05035121

N201702034

Details and patient eligibility

About

The purpose of this study was determine whether milk or soy milk supplements combined with resistance exercise improved sarcopenia in the elderly. This study was randomized controlled trail that recruited elderly people ≧65 years old with sarcopenia in the nursing home of Taipei Veterans General Hospital Su-Ao and Yuanshan Branch from June 2017 to December, 2017. The participants were divided into three groups, such as control, milk supplement and soy milk supplement. The milk and soy milk groups provided 200 mL milk or soy milk two times per day. Moreover, all participants joined the resistance exercise training program, three times per week (30 min/time). After 12 weeks, the anthropometry, sarcopenia index, blood biochemical index, nutrition status index, inflammation index, insulin resistance index, and dietary intake were measured.

Full description

The anthropometry data included body weight and body fat. The sarcopenia index included appendicular skeletal muscle mass index, calf circumferences, hand grip and gait speed. Moreover, blood biochemical index (liver function as ALT, kidney function as creatinine), nutrition status index (prealbumin, 25-hydroxyvitamin D) were also analyzed. The blood hsCRP level was as inflammation index and insulin resistance index included fasting blood sugar, insulin, HbA1c and HOMA-IR. The daily dietary intake were also recorded.

Enrollment: 35 patients

Sex: All

Ages: 65 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age ≧ 65 years old
• No allergies to milk and soy milk
• Sarcopenia cases (AWGS)
• Active ability

Exclusion criteria

• End-of-life patient or estimated death within six months
• Last stage of cancer
• Chronic kidney disease stage 4

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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35 participants in 3 patient groups, including a placebo group

milk supplement

Experimental group

Description:

The milk group provided 200 mL milk two times per day. The participants joined the resistance exercise training program, three times per week (30 min/time) during 12 weeks.

Treatment:

Dietary Supplement: milk supplement

Behavioral: resistance exercise

soy milk supplement

Experimental group

Description:

The soy milk group provided 200 mL soy milk two times per day. The participants joined the resistance exercise training program, three times per week (30 min/time) during 12 weeks.

Treatment:

Dietary Supplement: soy milk supplement

Behavioral: resistance exercise

control

Placebo Comparator group

Description:

The participants joined the resistance exercise training program, three times per week (30 min/time) during 12 weeks.

Treatment:

Behavioral: resistance exercise