Status and phase
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About
This longitudinal study tests the hypothesis that obesity affects drug pharmacology of acid suppression medications in children.
Full description
The purpose of this research study is to see how the body breaks down certain medicines. Many medicines are broken down in the liver. The liver is an organ in the belly. A person's age, size, genetics (DNA), and the health of their liver decide how quickly the body breaks down medicines and how much medication a person needs to take. Everybody's liver has some fat in it, but the amount of fat is different from person to person. The purpose of this study is to see if the amount of fat in the liver affects how quickly acid suppression medications start and stop working and get removed from the body.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
6-21 years of age
Obese and non-obese individuals
Otherwise healthy; or otherwise healthy with diagnosis of GERD, NAFLD, chronic abdominal pain or obesity, according to report of medical history and/or review of the medical record
Receiving or not receiving pantoprazole or lansoprazole for routine medical care
MRI Hoop Test Clearance
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
150 participants in 2 patient groups
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Central trial contact
Jaylene D Weigel; Simone Lax
Data sourced from clinicaltrials.gov
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