Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical)

University at Buffalo (UB)

Status: Completed

Conditions: Primary Progressive Multiple Sclerosis

Treatments: Other: Ocrelizumab

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05974839

00007536

Details and patient eligibility

About

The goal of this non-interventional, observational study is to determine whether cortical pathology can be slowed down by use of ocrelizumab.

Full description

To study the effect of ocrelizumab on cortical lesion accumulation in patients with primary-progressive multiple sclerosis participating in the ORATORIO: a post-hoc analysis of a double-blind, randomized, phase 3, placebo-controlled study.

Enrollment: 732 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient participating in the ORATORIO study
• MRI scans available at baseline
• Presence of T2-weighted image (WI) (FLAIR, T2/PD), and 2D/3D T1-WI at baseline

Exclusion criteria

• None