Effect of Oligopin® on Blood Pressure.

Technological Centre of Nutrition and Health, Spain

Status: Completed

Conditions: Hypertension; Blood Pressure

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Oligopin®

Study type: Interventional

Funder types: Other

Identifiers

NCT02063477

Oligo_extract

Details and patient eligibility

About

The objective of the study is to evaluate the effect of consumption of a food supplement rich in procyanidins extracted from the bark of French pine, Oligopin®, on blood pressure of people with mild / moderate degree of hypertension. Furthermore, the effect Oligopin® consumption on markers involved in the development of hypertension, and endothelial function in key enzymes that regulate blood pressure, inflammation and oxidation are considered. Also, try to advance the understanding of the molecular mechanisms that regulate blood pressure.

Enrollment: 24 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• early stages of hypertension (systolic BP ≥ 140 and ≤ 159 mm Hg) and/or diastolic BP: ≥ 90 and ≤ 99 mm Hg
• not receiving BP-lowering medication.
• obtained written informed consent before the initial screening visit.

Exclusion criteria

• Body Mass Index (BMI) > 30 kg/m2
• taking antihypertensive medications
• smoking
• pregnant or who intends to become pregnant
• wife in breastfeeding period
• persons with a self-reported history of clinical cardiovascular disease, cancer, chronic kidney disease (or a serum creatinine ≥ 1.7 mg/dL for men and ≥ 1.5 mg/dL for women) hypercholesterolemia (LDL-c ≤ 189 mg/dL, diabetes mellitus (or serum glucose ≥126 mg/dL), or consumption of more than 14 drinks of alcoholic beverages per week.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

24 participants in 2 patient groups, including a placebo group

Product one

Placebo Comparator group

Description:

150 mg (maltodextrin)/day (75 mg maltodextrin included in 280 mg/gelule; 2 times/day: morning and evening) of Placebo plus Dietary Approaches to Stop Hypertension (DASH)

Treatment:

Dietary Supplement: Placebo

Product two

Active Comparator group

Description:

150 mg Oligopin/day (75mg Oligopin included in 280mg/gelule; 2 times/day: morning and evening) of Oligopin® plus Dietary Approaches to Stop Hypertension (DASH)

Treatment:

Dietary Supplement: Oligopin®