Effect of Ondansetron for Withdrawal Symptoms

Stanford University

Status: Completed

Conditions: Substance Withdrawal Syndrome

Treatments: Drug: Ondansetron and Placebo crossover

Study type: Interventional

Funder types: Other

Identifiers

NCT00695864

14228

SU-05222008-1180

Details and patient eligibility

About

We hope to determine whether Ondansetron, an anti-nausea medication, works to help relieve withdrawal symptoms experienced while the patient is being weaned off opioid medications. This medication has shown anecdotal evidence of being affective for the treatment of withdrawal symptoms and we hope to determine whether this is affective.

Enrollment: 31 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:-Over 18 years of age

• No medical contraindications to medication
• Able to fulfill research procedures Exclusion Criteria:-Subjects who are unable to respond to our questionnaires or to stimuli as required by the experimental protocol will be excluded.
• Subjects will be excluded if they have a history of significant psychiatric disorders that would prevent them from engaging in a treatment program.
• Participating in other studies that would interfere with the procedures in this study
• Known or apparent pregnancy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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31 participants in 2 patient groups, including a placebo group

Placebo - sugar pill

Placebo Comparator group

Description:

Placebo - sugar pill

Treatment:

Drug: Ondansetron and Placebo crossover

Ondansetron

Experimental group

Description:

Ondansetron

Treatment:

Drug: Ondansetron and Placebo crossover