Effect of Opioid Cessation on Opioid-Induced Esophageal Dysfunction

Mayo Clinic

Status: Enrolling

Conditions: Opioid-Induced Esophageal Dysfunction

Treatments: Behavioral: Opioid cessation; Other: No opioid cessation

Study type: Observational

Funder types: Other

Identifiers

NCT05854303

23-001879

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED).

Enrollment: 26 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

- Patients enrolled in the Pain Rehabilitation Center for opioid cessation, with or without esophageal symptoms.

Exclusion criteria

• Inability to provide informed consent.
• Patients with previous gastroesophageal surgery or pneumatic dilation.
• Esophageal botulinum toxin injection within the prior 12 months.
• Esophageal stricture
• Achalasia types I and II
• Allergy to Lidocaine or other local anesthetics
• Subjects on anticoagulation
• Bilateral nasal obstruction
• Pregnancy or breast feeding

Trial design

26 participants in 2 patient groups

Opioid Cessation

Description:

Subjects able to complete opioid cessation.

Treatment:

Behavioral: Opioid cessation

Non-Opioid Cessation

Description:

Subjects unable to complete opioid cessation.

Treatment:

Other: No opioid cessation