Effect of Oral Carbohydrate on Serum S-100β Protein and Development of Postoperative Delirium in Elderly Patients

Yonsei University Health System (YUHS)

Status: Completed

Conditions: Inflammation; Delirium; Insulin Resistance

Treatments: Dietary Supplement: Allocated to Placebo group; Dietary Supplement: Allocated to Carbohydrated group

Study type: Interventional

Funder types: Other

Identifiers

NCT02706522

3-2015-0317

Details and patient eligibility

About

This study is to evaluate the effects of preoperative carbohydrate intake on perioperative neuroinflammation and development of delirium.

Full description

Perioperative insulin resistance may primarily contribute to development of postoperative delirium in high risk patients. Preoperative administration of oral carbohydrate reduces insulin resistance. The investigators aimed to investigate the influence of carbohydrate loading on the serum level of S-100β, a surrogate marker of delirium, and the incidence of postoperative delirium in elderly patients.

Enrollment: 3 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing total hip replacement or total knee replacement surgery

Exclusion criteria

• Diabetes
• Dementia
• Gastro-esophageal reflux
• Upper gastrointestinal motility disorder
• Inflammatory bowel disease
• Intraperitoneal malignancy history
• Inability to perform cognitive function test

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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3 participants in 2 patient groups, including a placebo group

Allocated to Carbohydrated group

Experimental group

Description:

1. Patients was administered in hospital 2. Randomization 3. Patient was allocated to Carbohydrated group 4. Patients received 400 mL of oral isotonic glucose (No NPO®, Daesang, Korea) 12 hours before anesthesia and 400 mL 2 hours before. CHL composition was standard: 12.5 g of carbohydrate per 100 mL, 12% monosaccharide, 12% disaccharide, 76% polysaccharide, 250 mOsm/kg and 50 kcal.

Treatment:

Dietary Supplement: Allocated to Carbohydrated group

Allocated to Placebo group

Placebo Comparator group

Description:

1. Patients was administered in hospital 2. Randomization 3. Patient was allocated to Placebo group 4. Patients received 400 mL of water 12 hours before anesthesia and 400 mL 2 hours before anesthesia.

Treatment:

Dietary Supplement: Allocated to Placebo group