Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers (WATERNAL)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Fluid Therapy; Pharmacodynamics; Intravenous Fluids; Fluid Challenge; Fluid Responsiveness

Treatments: Other: oral water; Other: saline intravenous administration

Study type: Interventional

Funder types: Other

Identifiers

NCT05153837

PI2019_843_0064

Details and patient eligibility

About

Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

Enrollment: 59 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteer subject between 18 and 30 years old
• patient with a regular sinus rhythm
• Echogenic subject.
• Fasting of solid and liquid since 8 h
• Subject in regular sinus rhythm.
• Written consent signed.

Exclusion criteria

• Any known cardiac, renal or endocrine pathology.
• Arrhythmia rhythm disorder by atrial fibrillation
• Pregnant or nursing woman.
• Pathology versus indicating Nacl administration.
• Person under tutors or curators or deprived of liberty.
• Person not affiliated to a social security scheme.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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59 participants in 2 patient groups

oral water

Experimental group

Description:

Experimental group: oral administration of 500 ml of water.

Treatment:

Other: oral water

intravenous

Active Comparator group

Description:

Active comparator: Administration of 500 mL of saline (NaCl 0.9%) administered by the venous route

Treatment:

Other: saline intravenous administration