Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway

Babylon University

Status: Completed

Conditions: Infertility Unexplained

Treatments: Dietary Supplement: Zinc Sulfate

Study type: Interventional

Funder types: Other; NETWORK

Identifiers

NCT03361618

Babil-5

Details and patient eligibility

About

Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.

Full description

The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.

Enrollment: 120 patients

Sex: Male

Ages: 26 to 36 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The presence of asthenozoospermia in the semen sample.
• Must be unable to reproduce.

Exclusion criteria

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Zinc sulfate

Experimental group

Description:

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Treatment:

Dietary Supplement: Zinc Sulfate

Healthy control

No Intervention group

Description:

60 fertile (age 31.6±3.3 year) men, no treatment.