Effect of Orange Juice on Glycemic Response

University of Leeds

Status: Completed

Conditions: Effect of Food on Postprandial Hyperglycemia

Treatments: Other: test meal 2; Other: test meal 3; Other: control; Other: test meal 1

Study type: Interventional

Funder types: Other

Identifiers

NCT03522896

MEEC15-044b

Details and patient eligibility

About

Orange juice naturally contains high concentrations of hesperidin, which affects glucose absorption in in vitro experiments. This study is to test if hesperidin and other components of orange juice (not other sugars or organic acids) affect the post-prandial blood glucose concentration derived from sugars already present in the orange juice.

Full description

Healthy volunteers will consume orange juice with added water or food-grade hesperidin.

Enrollment: 10 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• fasting blood glucose below 5.9 mM

Exclusion criteria

• fasting glucose above 6 mM pregnant

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 4 patient groups, including a placebo group

control meal

Placebo Comparator group

Description:

glucose, fructose, sucrose, malic acid and citric acid in water

Treatment:

Other: control

test meal 1

Experimental group

Description:

orange juice with added hesperidin (low dose)

Treatment:

Other: test meal 1

test meal 2

Experimental group

Description:

orange juice with added hesperidin (high dose)

Treatment:

Other: test meal 2

test meal 3

Experimental group

Description:

diluted orange juice with added hesperidin

Treatment:

Other: test meal 3