Effect of Oxygen During Percutaneous Coronary Intervention for Pain Relief (OXYPAIN)

Region Skane

Status and phase: Completed; Phase 2

Conditions: Angina

Treatments: Drug: Regular nasal air; Drug: Nasal oxygen

Study type: Interventional

Funder types: Other

Identifiers

NCT01413841

DELUCA2

Details and patient eligibility

About

Nasal oxygen is widely used as pain relief against ischemic pain during Percutaneous Coronary Intervention (PCI). However, to our knowledge no randomised clinical trials have tested this. In contrast, oxygen causes coronary artery vasoconstriction in man. Furthermore, a recent Cochrane meta-analysis has shown no evidence of beneficial effect of oxygen for patients with acute myocardial infarction (with normal blood saturation. The investigators therefore wanted to examine if oxygen reduces ischemic pain during PCI for stable angina or NSTEMI.

Enrollment: 300 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable angina or NST-ACS undergoing PCI

Exclusion criteria

• Blood oxygen <95%
• Cognitive dysfunction
• STEMI
• Intubation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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300 participants in 2 patient groups, including a placebo group

Nasal oxygen

Active Comparator group

Description:

3 liter per minute

Treatment:

Drug: Nasal oxygen

Nasal Air

Placebo Comparator group

Description:

3 l regular nasal air

Treatment:

Drug: Regular nasal air