Effect of Oxygen-supply on 6-Minute-Walking-Distance of COPD III/IV-patients

Schön Klinik Berchtesgadener Land

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: 6MWT with oxygen; Other: 6MWT with medical air

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00886639

BGL O2

Details and patient eligibility

About

The aim of this study is to investigate the six-minute-walking-distance of COPD-patients with breathing oxygen in comparison to breathing normal air. Patients, who increase their walking-distance about more than 15% or 35m only because of breathing oxygen, are so-called "Oxygen Responders." The study is aimed to find attributes of Oxygen Responder and to investigate, if a patient can change the "respond" with higher performance and endurance.

Enrollment: 127 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic obstructive pulmonary disease III/IV

Exclusion criteria

• Severe exacerbations in the last 4 weeks prior to begin of study (definition of exacerbation: symptoms on more than 3 days with a relevant change in drug therapy (cortisone, antibiotics))
• Severe exacerbation during rehabilitation
• Cardiac insufficiency

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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127 participants in 2 patient groups

First of 2 6-minute-walking test with oxygen

Other group

Description:

Continuous flow of 2 liters per minute First with oxygen, second with medical air

Treatment:

Other: 6MWT with medical air

Other: 6MWT with oxygen

First of 2 6-minute-walking tests with medical air

Other group

Description:

Medical air is compressed room air. First test with medical air, second with oxygen

Treatment:

Other: 6MWT with medical air

Other: 6MWT with oxygen