Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy

Kanuni Sultan Suleyman Training and Research Hospital

Status and phase: Completed; Phase 4

Conditions: Myomectomy

Treatments: Other: saline; Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT03308643

2016/3

Details and patient eligibility

About

To evaluate the effects of oxytocin infusion during abdominal myomectomy.

Full description

Myomectomy is indicated for symptomatic uterine fibroids. Fibroids have blood supply and 20% of the abdominal myomectomy cases might require blood transfusion because of the nature of the surgery. Oxytocin infusion is one of the intervention to decrease blood loss during myomectomy. To evaluate the effects and benefits of oxytocin infusion during abdominal myomectomy we decide to conduct this randomized study.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-50
• Patients who are candidate for abdominal myomectomy

Exclusion criteria

• History of previous myomectomy.
• Suspected malignancy
• Patients with preoperative anemia
• Patients using hormonal treatments before the surgery.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Oxytocin infusion

Experimental group

Description:

Patients will receive intravenous oxytocin infusion just before the surgery after the induction of general anesthesia.

Treatment:

Drug: Oxytocin

Placebo

Placebo Comparator group

Description:

Patients will receive pure normal saline infusion at the same rate and volume just before the surgery after the induction of general anesthesia.

Treatment:

Other: saline