Effect of Ozone Gel on Treatment of Chronic Periodontitis

October 6 University

Status and phase: Completed; Phase 2

Conditions: Periodontal Diseases

Treatments: Procedure: scaling and root planing; Drug: Ozonated olive oil gel; Drug: placebo gel

Study type: Interventional

Funder types: Other

Identifiers

NCT02066337

mn1965

Details and patient eligibility

About

To evaluate the efficacy of locally delivered ozone gel as an adjunct to conventional periodontal therapy on selected clinical parameters as well as alveolar bone density (BD) and superoxide dismutase (SOD) activity in patient with chronic periodontitis.

Full description

In this study, the investigators tested the effect of ozone gel as a local delivery system in treatment of chronic periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, a more rise in BD values as well as greater reduction in SOD activity compared to scaling and root planing (SRP) alone.

Enrollment: 40 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. The participant's age ranged between 30 and 60 years.
2. All of the patients suffered from chronic periodontitis with attachment loss ≥ 5mm.
3. Willingness to participate and sign the informed consent.

Exclusion criteria

1. Any systemic disease that affect the periodontium.
2. Pregnancy, lactation, postmenopausal women
3. People who take anti-inflammatory drugs, antibiotics or vitamins within the previous 3 month.
4. People who use mouth washes regularly
5. Heavy smoking (> 10 cigarettes/day)
6. History of alcohol abuse.
7. Participation in other clinical trials.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

placebo gel

Placebo Comparator group

Description:

scaling and root planing with placebo gel

Treatment:

Procedure: scaling and root planing

Drug: placebo gel

Ozonated olive oil gel

Active Comparator group

Description:

scaling and root planing with Ozonated olive oil gel

Treatment:

Procedure: scaling and root planing

Drug: Ozonated olive oil gel