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Effect of Ozone Gel on Treatment of Chronic Periodontitis

O

October 6 University

Status and phase

Completed
Phase 2

Conditions

Periodontal Diseases

Treatments

Procedure: scaling and root planing
Drug: Ozonated olive oil gel
Drug: placebo gel

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

To evaluate the efficacy of locally delivered ozone gel as an adjunct to conventional periodontal therapy on selected clinical parameters as well as alveolar bone density (BD) and superoxide dismutase (SOD) activity in patient with chronic periodontitis.

Full description

In this study, the investigators tested the effect of ozone gel as a local delivery system in treatment of chronic periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, a more rise in BD values as well as greater reduction in SOD activity compared to scaling and root planing (SRP) alone.

Enrollment

40 patients

Sex

All

Ages

30 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. The participant's age ranged between 30 and 60 years.
  2. All of the patients suffered from chronic periodontitis with attachment loss ≥ 5mm.
  3. Willingness to participate and sign the informed consent.

Exclusion criteria

  1. Any systemic disease that affect the periodontium.
  2. Pregnancy, lactation, postmenopausal women
  3. People who take anti-inflammatory drugs, antibiotics or vitamins within the previous 3 month.
  4. People who use mouth washes regularly
  5. Heavy smoking (> 10 cigarettes/day)
  6. History of alcohol abuse.
  7. Participation in other clinical trials.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

40 participants in 2 patient groups, including a placebo group

placebo gel
Placebo Comparator group
Description:
scaling and root planing with placebo gel
Treatment:
Procedure: scaling and root planing
Drug: placebo gel
Ozonated olive oil gel
Active Comparator group
Description:
scaling and root planing with Ozonated olive oil gel
Treatment:
Procedure: scaling and root planing
Drug: Ozonated olive oil gel

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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