Effect of Panax Ginseng C.A. Mey Extract on Liver Function in Adults

Pusan National University Yangsan Hospital

Status: Enrolling

Conditions: Liver Diseases

Treatments: Dietary Supplement: Placebo group; Dietary Supplement: Panax Ginseng C.A. Mey Extract group

Study type: Interventional

Funder types: Other

Identifiers

NCT03775837

02-2018-031

Details and patient eligibility

About

The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of Panax Ginseng C.A. Mey Extract on liver function in adults for 8 weeks.

Full description

Previous studies have indicated that Panax Ginseng C.A. Mey Extract may have the ability to improve liver function. Therefore, the investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects of the Panax Ginseng C.A. Mey Extract on liver function in adults; the safety of the compound are also evaluate. The Investigators examine AST, ALT, GGT, and other metabolic parameters at baseline, as well as after 4 and 8 weeks of intervention. Sixty adults were administered either 600 mg of Panax Ginseng C.A. Mey Extract or a placebo each day for 8 weeks;

Enrollment: 60 estimated patients

Sex: All

Ages: 19 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ALT ranging from upper limit of reference to three times of upper limit

Exclusion criteria

• Abnormal liver or renal function (i.e., serum aminotransferase activity > 3 times of upper limit of reference range and serum creatinine concentrations > 1.2 mg/dL)
• Diabetes (diagnosed clinically or fasting glucose level > 126 mg/dL)
• History of viral hepatitis or cancer
• Uncontrolled hypertension
• History of serious cardiac disease such as angina or myocardial infarction
• History of gastrectomy
• History of medication for psychiatric disease
• Administration of oriental medicine including herbs within the past 4 weeks

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

Panax Ginseng C.A. Mey Extract group

Experimental group

Description:

This group takes Panax Ginseng C.A. Mey Extract for 8 weeks

Treatment:

Dietary Supplement: Panax Ginseng C.A. Mey Extract group

Placebo group

Placebo Comparator group

Description:

This group takes placebo for 8 weeks

Treatment:

Dietary Supplement: Placebo group