Effect of Paracetamol, Dexketoprofen Trometamol, Lidocaine Spray, Pethidine and Diclofenac Sodium Application for Pain Relief During Fractional Curettage

Kayseri Education and Research Hospital

Status: Completed

Conditions: Pain and Curettage

Treatments: Drug: comparison of pain relievers during curattage; Drug: comparison of pain relievers

Study type: Interventional

Funder types: Other

Identifiers

NCT01993589

{kayseriERH}

Details and patient eligibility

About

Patients frequently experience pain from moderate to severe during gynecologic procedures. This study is a prospective, randomized, placebo-controlled trial and aimed to investigate the analgesic efficacy of preoperative oral dexketoprofen trometamol, intravenous paracetamol, lidocaine spray, pethidine and diclofenac sodium on fractional curettage procedure.

Full description

A total of 144 mutiparous subjects randomly allocated one of six groups. The first group (control group) consisted of 22 participants and they did not receive any treatment. The second group consisted of 26 participants receiving oral 25 mg dexketoprofen trometamol. The third group consisted of 23 participants receiving 2 puff lidocaine sprays on cervical mucosa. The forth group consisted of 25 participants receiving 100 mg pethidine. The fifth group consisted of 23 participants receiving 1000 mg intravenous paracetamol and the sixth group consisted of 25 participants receiving diclofenac sodium.

Enrollment: 144 patients

Sex: Female

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• multiparous participants
• abnormal uterine bleeding
• postmenopausal bleeding
• myoma uteri causing menometrorrhagia
• cervical polyp
• tamoxifen treatment for breast cancer
• adnexial mass

Exclusion criteria

• abortions
• pregnancy
• primiparity
• diabetes mellitus
• tendency to bleed such as thrombocytopenia
• factor deficiency
• functional disorders of platelets

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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144 participants in 6 patient groups

Control group

No Intervention group

Description:

Control group

Pain reliever

Active Comparator group

Description:

1000 mg paracetamol (Parol 1 g Atabay ilaç Turkey)

Treatment:

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Dexketoprofen trometamol

Active Comparator group

Description:

25 mg oral Dexofen Atabay ilaç Turkey

Treatment:

Drug: comparison of pain relievers

Lidocaine spray

Active Comparator group

Description:

2 puff on cervical mucosa (Xylocain Pump 100 Mg 50 Ml Sprey Astra Zeneca)

Treatment:

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

pethidine

Active Comparator group

Description:

Aldolan 100 mg Liba Laboratuarı İstanbul Turkey

Treatment:

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

diclofenac sodium

Active Comparator group

Description:

Dicloron amp 75 mg Deva İlaç Levent İstanbul/Turkey

Treatment:

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage

Drug: comparison of pain relievers during curattage