Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure

Kyoto University

Status and phase: Completed; Phase 4

Conditions: Endothelium-derived Factors; Elderly; Congestive Heart Failure

Treatments: Other: Passive leg cycle exercise with stretching and resistance training; Other: Stretching and resistance training

Study type: Interventional

Funder types: Other

Identifiers

NCT00733161

20795203

Details and patient eligibility

About

The purpose of this study is to determine the effect of passive exercise on systemic endothelial function in elderly patients with chronic heart failure.

Full description

Endothelial function is known to be impaired in patients with chronic heart failure (CHF) and impaired endothelial function has been reported to be associated with an increased mortality risk in those subjects. Although systemic exercise training has been demonstrated to improve endothelial dysfunction in patients with CHF, elderly patients with severely impaired exercise capacity could not engaged in usual exercise training using ordinal ergometer. Those patients are able to join stretching or very light resistance training. On the other hand, passive pedaling using strength ergometer has been reported to be useful in patients with severely impaired exercise capacity, but the safety and the efficacy of passive pedaling on endothelial function in old patients with CHF has not been previously reported.

Enrollment: 30 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of chronic heart failure
• Elderly patients aged ≧65 years
• Patients with severely reduced exercise capacity and cannot continue exercise with usual cycling ergometer for 5 minutes

Exclusion criteria

• Unstable hemodynamic status (uncontrolled arrhythmia, uncontrolled congestion, uncontrolled hypertension)
• Active infectious disease
• Malignancy
• Chronic obstructive pulmonary disease
• Dialysis
• Severe aortic valve disease
• With any hip, knee, ankle joint pain
• Hemiplegia
• Current smoker

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

1

Active Comparator group

Description:

Passive leg cycle exercise with stretching and resistance training

Treatment:

Other: Passive leg cycle exercise with stretching and resistance training

2

Active Comparator group

Description:

Stretching and resistance training

Treatment:

Other: Stretching and resistance training