Effect of Passive Smoking on Platelet Function and Endothelial Function

Kantonsspital Graubünden

Status

Completed

Conditions

Endothelial Function

Platelet Aggregation

Treatments

Other: secondhand smoke exposure

Study type

Interventional

Funder types

Other

Identifiers

NCT00923988

SHS-EF

Details and patient eligibility

About

Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood. In the present study, the researchers investigate the effects of short-term exposure to secondhand smoke on platelet function and peripheral microvascular endothelial function in healthy individuals. For this purpose, platelet function and endothelial function are measured before and after a 1-hour exposure to secondhand smoke in a concentration that is encountered in bars and restaurants without smoke-free policies. The researchers' hypothesis is that short-term exposure leads to platelet activation and impairment of endothelial function.

Enrollment

40 estimated patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy individuals
nonsmokers
no regular medication (in particular no drugs affecting platelet function or vascular function)

Exclusion criteria

exposition to secondhand smoke within 1 week before inclusion
use of drugs affecting platelet function or vascular function within 1 week before study inclusion