Effect of PDRN in Post-operative Scars

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Scar

Treatments: Procedure: Polydeoxyribonucleotide (PDRN)

Study type: Interventional

Funder types: Other

Identifiers

NCT05149118

B-1811-507-005

Details and patient eligibility

About

The investigators aimed to evaluate the efficacy of PDRN administration in early wound healing phase on prevention of post-operative scars after open thyroidectomy.

Enrollment: 22 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants who underwent open thyroidectomy between February 2019 and March 2021 at the Thyroid Cancer Center, Department of otorhinolaryngology, Seoul National University Bundang Hospital

Exclusion criteria

• age younger than 20 years or older than 60 years
• history of keloid development
• requirement for modified radical neck dissection
• previous neck surgery
• current pregnancy or breast feeding
• allergy to PDRN
• taking medications that may affect inflammation and would healing such as isotretinoin, anti-cancer drugs, high dose corticosteroids, and anticoagulants
• uncontrolled medical diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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22 participants in 2 patient groups

PDRN injected group

Experimental group

Description:

The participants in treatment group had received two consecutive injections of PDRN one day and two days after the surgery. A total 1mL of PDRN was injected along the suture line at distance of 1cm in each session.

Treatment:

Procedure: Polydeoxyribonucleotide (PDRN)

Control group

No Intervention group

Description:

The participants in control group were left untreated.