Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

Tel Aviv University

Status: Unknown

Conditions: Glucose Control; Brain Activity

Treatments: Dietary Supplement: Glucose; Device: Stimulator

Study type: Interventional

Funder types: Other

Identifiers

NCT02969330

2366-16-SMC

Details and patient eligibility

About

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Age 18-65 years old.
• Body mass index 18 to 25 kg/m2
• Capable of giving informed consent

Exclusion criteria

• Pregnancy, or nursing
• Permanent pacemakers
• Metal prosthesis
• Skin disease
• Claustrophobia
• History of neurological disorders

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Glucose

Experimental group

Description:

Glucose ingestion

Treatment:

Dietary Supplement: Glucose

PES

Active Comparator group

Description:

Single session of short PES treatment before glucose ingestion.

Treatment:

Device: Stimulator

Dietary Supplement: Glucose