Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients

National University of Singapore

Status

Completed

Conditions

Periodontitis

Periodontal Attachment Loss

Periodontal Pocket

Periodontitis, Adult

Treatments

Device: SRP and Fotosan 630

Study type

Interventional

Funder types

Other

Identifiers

NCT03453476

NUSingapore

Details and patient eligibility

About

Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant. At baseline, 3rd month and 6th month, clinical parameters and cytokine pattern in gingival crevicular fluids (GCFs) were analysed.

Full description

Periodontal parameters and cytokine IL-1β, IL-6, IL-8, TNF-α, MMP-8 levels were analysed.

Enrollment

51 patients

Sex

All

Ages

21+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Adults who were medically fit or have medical condition that did not alter the outcome of periodontal treatment.
Females who were not pregnant or nursing.
Controlled diabetes mellitus with HbA1c < 7.5 mmol/L.
Not on any antibiotics or steroids 3 months prior to periodontal treatment.
Diagnosed to have either localized or generalized chronic or aggressive periodontitis (Armitage, 1999) with all 4 quadrants having at least 2 sites with probing depth ≥ 4 mm.
Consented to follow the non-surgical periodontal treatment (scaling and root planing) with PDT throughout the period of study, i.e. approximately 6 months.

Exclusion criteria