Effect of Physical Activity Pattern on Cardiometabolic Health (PACE)

Mass General Brigham

Status: Enrolling

Conditions: Life Style

Treatments: Behavioral: Exercise intervention

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05838508

2023P001025

R00HL148500 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this study is to understand the interaction between the circadian system and physical activity.

Participants will:

• complete 2 inpatient stays
• perform moderate exercise
• be provided with identical meals
• have frequent blood draws
• provide urine and saliva samples

Full description

The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.

Enrollment: 26 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-45 yr old
• Body mass index (BMI) 18.5 - 34.9 kg/m2
• No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
• Willing to adhere to the protocol requirements for the duration of the study

Exclusion criteria

• Currently smoking/vaping or 5 or more years of smoking/vaping
• Currently pregnant or breastfeeding
• History of drug or alcohol dependency
• History of psychiatric illness or disorder
• Any hospitalization due to COVID-19
• Inability to exercise for any reason
• Any known contraindication to exercise testing based on current ACSM guidelines

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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26 participants in 2 patient groups

Exercise A-B Intervention

Experimental group

Description:

The Exercise A first, then the Exercise B intervention.

Treatment:

Behavioral: Exercise intervention

Exercise B-A Intervention

Experimental group

Description:

The Exercise B first, then the Exercise A intervention.

Treatment:

Behavioral: Exercise intervention