Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

Rigshospitalet

Status: Completed

Conditions: Endothelial Function; Exercise Capacity; Heart Transplantation

Treatments: Other: Intensive physical exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01028599

H-D-2009-004

Details and patient eligibility

About

The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.

Full description

To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.

Enrollment: 30 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heart transplant recipients > 1 year after transplantation

Exclusion criteria

• Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Exercise

Experimental group

Treatment:

Other: Intensive physical exercise