Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients

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Rigshospitalet

Status

Completed

Conditions

Endothelial Function
Exercise Capacity
Heart Transplantation

Treatments

Other: Intensive physical exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT01028599
H-D-2009-004

Details and patient eligibility

About

The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively. Effect on the hormones and the immune system is evaluated using blood samples.

Full description

To investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training or control. Vascular function is measured non-invasively using forearm flow mediated dilatation. Effect on the blood natriuretic peptides and the inflammatory markers is evaluated using blood samples at baseline and after the training or control period.

Enrollment

30 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

* Heart transplant recipients \> 1 year after transplantation

Exclusion criteria

* Recent rejection, severe renal dysfunction, graft dysfunction, allograft vasculopathy, cancer, inability to exercise.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

30 participants in 1 patient group

Exercise
Experimental group
Treatment:
Other: Intensive physical exercise

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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