Effect Of Piperine In Patients With Oropharyngeal Dysphagia (FIS 2009_2)

Hospital de Mataró

Status and phase: Completed; Phase 2; Phase 1

Conditions: Deglutition Disorders

Treatments: Drug: Piperine

Study type: Interventional

Funder types: Other

Identifiers

NCT01383694

FIS 22/09

Details and patient eligibility

About

Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age>18
• History of swallowing difficulties associated with aging and/or neurological diseases (neurodegenerative or non-progressive neurological diseases)
• Study explained and written subject information given
• Informed consent signed

Exclusion criteria

• Patients suffering idiosyncratic phenomena or who are allergic to any medication, especially iodinated contrast media
• Patients suffering major respiratory disease or undergoing any type of surgery in the three months prior to the study
• Patients with a background of alcohol dependence or other drug dependence
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Piperine Dose 1

Experimental group

Description:

Piperine 1 mM

Treatment:

Drug: Piperine

Piperine Dose 2

Experimental group

Description:

Piperine 150 microM

Treatment:

Drug: Piperine