Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Platelets-rich Plasma; Meniscus Disorder; Cartilage Injury; Osteoarthritis Knees Both

Treatments: Drug: Sodium hyaluronate injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06082531

KY20232210

Details and patient eligibility

About

To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for the treatment of joint injury.

Enrollment: 300 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The age range of the participants was 20 to 60 years old. Through a comprehensive clinical and imaging examination, it was conclusively determined that the individuals had knee osteoarthritis or experienced injuries to the cart, and meniscus surrounding the knee joint.
• The preoperative routine tests and examinations revealed no contraindications.
• Revised sentence: "Informed consent of the patient

Exclusion criteria

• The platelet count or function exhibits significant abnormalities、Systemic infection transmitted through the bloodstream.
• Prolonged usage of anti-inflammatory drugs and systemic corticoid administration.
• In injection site or damage to the skin.
• Patients with tumors or undergoing radiotherapy and chemotherapy.
• Pregnant or breastfeeding women.
• Individuals with mental illnesses who are unable to cooperate with follow-up procedures.
• Contraindications for MRI、Patients or their families do consent to participate in the study.
• Other circumstances that render participation in the study unsuitable.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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300 participants in 3 patient groups

Preoperative

No Intervention group

postoperative (6 weeks)

Experimental group

Description:

The patients were injected with PRP.

Treatment:

Drug: Sodium hyaluronate injection

postoperative (3 months)

Experimental group

Description:

The patients were injected with PRP.

Treatment:

Drug: Sodium hyaluronate injection