Effect of Positive End Expiratory Pressure (PEEP) on Cerebral Oxymetry During Laparoscopy

Gachon University Gil Medical Center

Status: Completed

Conditions: Cerebral Ischemia

Treatments: Procedure: zero end-expiratory pressure; Procedure: positive end expiratory pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT01436812

GIRBA2551 (Registry Identifier)

Details and patient eligibility

About

The investigators hypothesized that positive end expiratory pressure (PEEP) would increase the regional oxygen saturation (rSO2).

Full description

The investigators hypothesized that PEEP would increase the rSO2 during laparoscopic surgery by improving oxygenation.

Enrollment: 30 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA PS I or II adult patient undergoing laparoscopic low anterior resection with Trendelenburg position

Exclusion criteria

• Patients with history of cerebrovascular disease, coronary occlusive disease and/or obesity (body mass index > 30) were excluded from this study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

zero end-expiratory pressure

Placebo Comparator group

Description:

not applying PEEP during operation just applying TV=IBW\*6-8ml IBW = (male; 50+0.91\[(Ht-cm)-152.4\], female; 45.5 +0.91\[(Ht-cm)-152.4\], RR 8-12/min,

Treatment:

Procedure: positive end expiratory pressure

positive end expiratory pressure

Active Comparator group

Description:

applying PEEP 10cmH2O during operation just applying TV=IBW\*6-8ml IBW = (male; 50+0.91\[(Ht-cm)-152.4\], female; 45.5 +0.91\[(Ht-cm)-152.4\], RR 8-12/min,

Treatment:

Procedure: zero end-expiratory pressure