Effect of Povidone-iodine 5% Vs 1% on the Ocular Surface in Intravitreal Injections of Anti-VEGF (anti-VEGF)

José Gerardo García Aguirre

Status: Completed

Conditions: Dry Eye

Treatments: Procedure: Change of normal concentration of povidone-iodine 5% to 1%

Study type: Interventional

Funder types: Other

Identifiers

NCT06710951

RE-21-02

Details and patient eligibility

About

Objective and subjective comparison between the use of povidone-iodine 1% vs 5% as antiseptic in patients that need anti-VEGF intravitreal injection

Full description

Randomized, prospective clinical trial. One group was intervened with povidone-iodine at 5% and the other at 1% as antiseptic for anti-VEGF intravitreal injection. Each patient was evaluated before and after the injection of anti-VEGF for tear break up time, bulbar redness and ocular surface satining with fluorescein. Pain perception was also evaluated 15 minutes after the injection and 48 hours after.

Enrollment: 88 patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Having anti-VGEF intravitreal injection scheduled
• Informed consent signed

Exclusion Criteria

• Under 45 years
• Opacity that prevents ophthalmological evaluation and fixation
• Patients with severe dry eye
• Patients with signs of infection on the ocular surface
• Allergy to iodine
• Pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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88 participants in 2 patient groups

Povidone-iodine 1%

Experimental group

Description:

Povidone-iodine 1% was used as antiseptic during anti-VEGF intravitreal injection

Treatment:

Procedure: Change of normal concentration of povidone-iodine 5% to 1%

Povidone-iodine 5%

Active Comparator group

Description:

Povidone-iodine 5% was used as antiseptic during anti-VEGF intravitreal injection

Treatment:

Procedure: Change of normal concentration of povidone-iodine 5% to 1%