Effect of Pre-emptive Dose of Prednisone Versus Placebo in Impacted Third Molar Surgery

University Magna Graecia

Status and phase

Completed

Phase 4

Conditions

Tooth, Impacted

Tooth Position Anomalies

Tooth Avulsion

Facial Swelling

Tooth Extraction Status Nos

Treatments

Drug: Prednisone

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT05830747

465/2020

Details and patient eligibility

About

The present study proposes to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus and pain after surgical removal of the mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.

Full description

This study aims to compare the effect of a single preoperative dose of prednisone versus placebo in terms of facial swelling, trismus, and pain after surgical removal of M3M in a split-mouth randomized controlled clinical trial. Facial swelling will be evaluated using an innovative three-dimensional digital technique.

Enrollment

34 patients

Sex

All

Ages

18 to 32 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients aged 18 to 32 years who required both M3M extractions were recruited
Good health status
Indication to surgical extraction of both M3M
Complete root formation
Surgical risk level classified as "Conventional" or "Moderate" according to Daugela et al. classification

Exclusion criteria

Person under the age of 18 or over 32
Allergy or contraindications to administration of corticosteroids
Acute infection in any of the teeth to be extracted
Patients with chronic liver disease, diabetes, immune system dysfunction, or haematological disease
Pregnancy or breastfeeding
History of treatment with antiresorptive drugs
Chronic kidney disease
History of systemic corticosteroid therapy in the past 4 weeks